New Approaches to Investigate Drug-Induced Hypersensitivity.
Identifieur interne : 000740 ( Main/Exploration ); précédent : 000739; suivant : 000741New Approaches to Investigate Drug-Induced Hypersensitivity.
Auteurs : Monday O. Ogese [Royaume-Uni] ; Shaheda Ahmed [Royaume-Uni] ; Ana Alferivic [Royaume-Uni] ; Catherine J. Betts [Royaume-Uni] ; Anne Dickinson [Royaume-Uni] ; Lee Faulkner [Royaume-Uni] ; Neil French [Royaume-Uni] ; Andrew Gibson [Royaume-Uni] ; Gideon M. Hirschfield [Royaume-Uni] ; Michael Kammüller [Suisse] ; Xiaoli Meng [Royaume-Uni] ; Stefan F. Martin [Allemagne] ; Philippe Musette [France] ; Alan Norris [Royaume-Uni] ; Munir Pirmohamed [Royaume-Uni] ; B Kevin Park [Royaume-Uni] ; Anthony W. Purcell [Australie] ; Colin F. Spraggs [Royaume-Uni] ; Jessica Whritenour [États-Unis] ; Dean J. Naisbitt [Royaume-Uni]Source :
- Chemical research in toxicology [ 1520-5010 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : Drug Hypersensitivity.
- immunology : Drug Hypersensitivity, Major Histocompatibility Complex.
- Animals, Biological Assay, Drug Industry, Genetic Predisposition to Disease, Humans, Phenotype, Risk Factors.
Abstract
The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.
DOI: 10.1021/acs.chemrestox.6b00333
PubMed: 27806199
Affiliations:
- Allemagne, Australie, France, Royaume-Uni, Suisse, États-Unis
- Bade-Wurtemberg, District de Fribourg-en-Brisgau
- Fribourg-en-Brisgau
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Ogese</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG</wicri:regionArea><wicri:noRegion>Cambridge CB4 0WG</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Shaheda" sort="Ahmed, Shaheda" uniqKey="Ahmed S" first="Shaheda" last="Ahmed">Shaheda Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Alferivic, Ana" sort="Alferivic, Ana" uniqKey="Alferivic A" first="Ana" last="Alferivic">Ana Alferivic</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Betts, Catherine J" sort="Betts, Catherine J" uniqKey="Betts C" first="Catherine J" last="Betts">Catherine J. 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Hirschfield</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham , Edgbaston, Birmingham B15 2TT, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham , Edgbaston, Birmingham B15 2TT</wicri:regionArea><wicri:noRegion>Birmingham B15 2TT</wicri:noRegion></affiliation></author><author><name sortKey="Kammuller, Michael" sort="Kammuller, Michael" uniqKey="Kammuller M" first="Michael" last="Kammüller">Michael Kammüller</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Institutes for Biomedical Research , Klybeckstrasse 141, CH-4057 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Institutes for Biomedical Research , Klybeckstrasse 141, CH-4057 Basel</wicri:regionArea><wicri:noRegion>CH-4057 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Xiaoli" sort="Meng, Xiaoli" uniqKey="Meng X" first="Xiaoli" last="Meng">Xiaoli Meng</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Stefan F" sort="Martin, Stefan F" uniqKey="Martin S" first="Stefan F" last="Martin">Stefan F. 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Purcell</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Spraggs, Colin F" sort="Spraggs, Colin F" uniqKey="Spraggs C" first="Colin F" last="Spraggs">Colin F. Spraggs</name><affiliation wicri:level="1"><nlm:affiliation>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY</wicri:regionArea><wicri:noRegion>Stevenage SG1 2NY</wicri:noRegion></affiliation></author><author><name sortKey="Whritenour, Jessica" sort="Whritenour, Jessica" uniqKey="Whritenour J" first="Jessica" last="Whritenour">Jessica Whritenour</name><affiliation wicri:level="1"><nlm:affiliation>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340</wicri:regionArea><wicri:noRegion>Connecticut 06340</wicri:noRegion></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. 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Ogese</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG</wicri:regionArea><wicri:noRegion>Cambridge CB4 0WG</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Shaheda" sort="Ahmed, Shaheda" uniqKey="Ahmed S" first="Shaheda" last="Ahmed">Shaheda Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Alferivic, Ana" sort="Alferivic, Ana" uniqKey="Alferivic A" first="Ana" last="Alferivic">Ana Alferivic</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Betts, Catherine J" sort="Betts, Catherine J" uniqKey="Betts C" first="Catherine J" last="Betts">Catherine J. Betts</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pathology Sciences, Drug Safety and Metabolism, AstraZeneca R&D , Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge CB4 0WG</wicri:regionArea><wicri:noRegion>Cambridge CB4 0WG</wicri:noRegion></affiliation></author><author><name sortKey="Dickinson, Anne" sort="Dickinson, Anne" uniqKey="Dickinson A" first="Anne" last="Dickinson">Anne Dickinson</name><affiliation wicri:level="1"><nlm:affiliation>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Alcyomics Ltd c/o Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne NE2 4HH</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne NE2 4HH</wicri:noRegion></affiliation></author><author><name sortKey="Faulkner, Lee" sort="Faulkner, Lee" uniqKey="Faulkner L" first="Lee" last="Faulkner">Lee Faulkner</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, Andrew" sort="Gibson, Andrew" uniqKey="Gibson A" first="Andrew" last="Gibson">Andrew Gibson</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham , Edgbaston, Birmingham B15 2TT, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Liver Research, NIHR Birmingham Liver Biomedical Research Unit, Institute of Immunology and Immunotherapy, University of Birmingham , Edgbaston, Birmingham B15 2TT</wicri:regionArea><wicri:noRegion>Birmingham B15 2TT</wicri:noRegion></affiliation></author><author><name sortKey="Kammuller, Michael" sort="Kammuller, Michael" uniqKey="Kammuller M" first="Michael" last="Kammüller">Michael Kammüller</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Institutes for Biomedical Research , Klybeckstrasse 141, CH-4057 Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Institutes for Biomedical Research , Klybeckstrasse 141, CH-4057 Basel</wicri:regionArea><wicri:noRegion>CH-4057 Basel</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Xiaoli" sort="Meng, Xiaoli" uniqKey="Meng X" first="Xiaoli" last="Meng">Xiaoli Meng</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Stefan F" sort="Martin, Stefan F" uniqKey="Martin S" first="Stefan F" last="Martin">Stefan F. Martin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Venereology, Allergy Research Group, University of Freiburg , Hauptstraße 7, 79104 Freiburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Venereology, Allergy Research Group, University of Freiburg , Hauptstraße 7, 79104 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Musette, Philippe" sort="Musette, Philippe" uniqKey="Musette P" first="Philippe" last="Musette">Philippe Musette</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and INSERM, University of Rouen , 905 Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology and INSERM, University of Rouen , 905 Rouen</wicri:regionArea><wicri:noRegion>905 Rouen</wicri:noRegion><wicri:noRegion>905 Rouen</wicri:noRegion></affiliation></author><author><name sortKey="Norris, Alan" sort="Norris, Alan" uniqKey="Norris A" first="Alan" last="Norris">Alan Norris</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Park, B Kevin" sort="Park, B Kevin" uniqKey="Park B" first="B Kevin" last="Park">B Kevin Park</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author><author><name sortKey="Purcell, Anthony W" sort="Purcell, Anthony W" uniqKey="Purcell A" first="Anthony W" last="Purcell">Anthony W. Purcell</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Spraggs, Colin F" sort="Spraggs, Colin F" uniqKey="Spraggs C" first="Colin F" last="Spraggs">Colin F. Spraggs</name><affiliation wicri:level="1"><nlm:affiliation>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY</wicri:regionArea><wicri:noRegion>Stevenage SG1 2NY</wicri:noRegion></affiliation></author><author><name sortKey="Whritenour, Jessica" sort="Whritenour, Jessica" uniqKey="Whritenour J" first="Jessica" last="Whritenour">Jessica Whritenour</name><affiliation wicri:level="1"><nlm:affiliation>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340</wicri:regionArea><wicri:noRegion>Connecticut 06340</wicri:noRegion></affiliation></author><author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. Naisbitt</name><affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea><wicri:noRegion>Liverpool L69 3GE</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemical research in toxicology</title><idno type="eISSN">1520-5010</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Assay</term><term>Drug Hypersensitivity (genetics)</term><term>Drug Hypersensitivity (immunology)</term><term>Drug Industry</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Major Histocompatibility Complex (immunology)</term><term>Phenotype</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Complexe majeur d'histocompatibilité (immunologie)</term><term>Dosage biologique</term><term>Facteurs de risque</term><term>Humains</term><term>Hypersensibilité médicamenteuse (génétique)</term><term>Hypersensibilité médicamenteuse (immunologie)</term><term>Industrie pharmaceutique</term><term>Phénotype</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Complexe majeur d'histocompatibilité</term><term>Hypersensibilité médicamenteuse</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Drug Hypersensitivity</term><term>Major Histocompatibility Complex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Assay</term><term>Drug Industry</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Phenotype</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dosage biologique</term><term>Facteurs de risque</term><term>Humains</term><term>Industrie pharmaceutique</term><term>Phénotype</term><term>Prédisposition génétique à une maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li></region><settlement><li>Fribourg-en-Brisgau</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ogese, Monday O" sort="Ogese, Monday O" uniqKey="Ogese M" first="Monday O" last="Ogese">Monday O. Ogese</name></noRegion><name sortKey="Ahmed, Shaheda" sort="Ahmed, Shaheda" uniqKey="Ahmed S" first="Shaheda" last="Ahmed">Shaheda Ahmed</name><name sortKey="Alferivic, Ana" sort="Alferivic, Ana" uniqKey="Alferivic A" first="Ana" last="Alferivic">Ana Alferivic</name><name sortKey="Betts, Catherine J" sort="Betts, Catherine J" uniqKey="Betts C" first="Catherine J" last="Betts">Catherine J. Betts</name><name sortKey="Dickinson, Anne" sort="Dickinson, Anne" uniqKey="Dickinson A" first="Anne" last="Dickinson">Anne Dickinson</name><name sortKey="Faulkner, Lee" sort="Faulkner, Lee" uniqKey="Faulkner L" first="Lee" last="Faulkner">Lee Faulkner</name><name sortKey="French, Neil" sort="French, Neil" uniqKey="French N" first="Neil" last="French">Neil French</name><name sortKey="Gibson, Andrew" sort="Gibson, Andrew" uniqKey="Gibson A" first="Andrew" last="Gibson">Andrew Gibson</name><name sortKey="Hirschfield, Gideon M" sort="Hirschfield, Gideon M" uniqKey="Hirschfield G" first="Gideon M" last="Hirschfield">Gideon M. Hirschfield</name><name sortKey="Meng, Xiaoli" sort="Meng, Xiaoli" uniqKey="Meng X" first="Xiaoli" last="Meng">Xiaoli Meng</name><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. Naisbitt</name><name sortKey="Norris, Alan" sort="Norris, Alan" uniqKey="Norris A" first="Alan" last="Norris">Alan Norris</name><name sortKey="Park, B Kevin" sort="Park, B Kevin" uniqKey="Park B" first="B Kevin" last="Park">B Kevin Park</name><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name><name sortKey="Spraggs, Colin F" sort="Spraggs, Colin F" uniqKey="Spraggs C" first="Colin F" last="Spraggs">Colin F. Spraggs</name></country><country name="Suisse"><noRegion><name sortKey="Kammuller, Michael" sort="Kammuller, Michael" uniqKey="Kammuller M" first="Michael" last="Kammüller">Michael Kammüller</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Martin, Stefan F" sort="Martin, Stefan F" uniqKey="Martin S" first="Stefan F" last="Martin">Stefan F. Martin</name></region></country><country name="France"><noRegion><name sortKey="Musette, Philippe" sort="Musette, Philippe" uniqKey="Musette P" first="Philippe" last="Musette">Philippe Musette</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Purcell, Anthony W" sort="Purcell, Anthony W" uniqKey="Purcell A" first="Anthony W" last="Purcell">Anthony W. Purcell</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Whritenour, Jessica" sort="Whritenour, Jessica" uniqKey="Whritenour J" first="Jessica" last="Whritenour">Jessica Whritenour</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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